| Short Description : | Rabbit polyclonal anti-Uveal autoantigen with coiled-coil domains and ankyrin repeats for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | UACA |
| Gene ID: | 55075 |
| Uniprot ID: | UACA_HUMAN |
| Immunogen: | Synthesized peptide derived from human UACA |
| Specificity: | This antibody detects endogenous levels of UACA at Human, Mouse |
| Function | Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1. Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation. |
| Protein Name | Uveal Autoantigen With Coiled-Coil Domains And Ankyrin Repeats |
| Database Links | Reactome: R-HSA-9013407Reactome: R-HSA-9627069 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonExpressed Diffusely In Cytoplasm |
| Alternative Antibody Names | Anti-Uveal Autoantigen With Coiled-Coil Domains And Ankyrin Repeats antibodyAnti-UACA antibodyAnti-KIAA1561 antibody |
Information sourced from Uniprot.org
![Anti-UACA antibody [AE-5] (STJ16101008)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/149724/302465/STJ16101008_1__59898.1646940649.jpg?c=1 "Anti-UACA antibody [AE-5] (STJ16101008)")
