Host: | Rabbit |
Applications: | WB/IHC-P/IP/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:2000IHC-P:1:100-1:200IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | U2AF1 |
Gene ID: | 102724594/7307 |
Uniprot ID: | U2AF1_HUMAN |
Immunogen Region: | 1-100 |
Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human U2AF1 (NP_006749.1). |
Immunogen Sequence: | MAEYLASIFGTEKDKVNCSF YFKIGACRHGDRCSRLHNKP TFSQTIALLNIYRNPQNSSQ SADGLRCAVSDVEMQEHYDE FFEEVFTEMEEKYGEVEEMN |
Function | Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron. |
Protein Name | Splicing Factor U2af 35 Kda SubunitU2 Auxiliary Factor 35 Kda SubunitU2 Small Nuclear Rna Auxiliary Factor 1U2 Snrnp Auxiliary Factor Small Subunit |
Database Links | Reactome: R-HSA-159236Reactome: R-HSA-72163Reactome: R-HSA-72187Reactome: R-HSA-73856 |
Cellular Localisation | NucleusNucleus Speckle |
Alternative Antibody Names | Anti-Splicing Factor U2af 35 Kda Subunit antibodyAnti-U2 Auxiliary Factor 35 Kda Subunit antibodyAnti-U2 Small Nuclear Rna Auxiliary Factor 1 antibodyAnti-U2 Snrnp Auxiliary Factor Small Subunit antibodyAnti-U2AF1 antibodyAnti-U2AF35 antibodyAnti-U2AFBP antibodyAnti-FP793 antibody |
Information sourced from Uniprot.org