• Western blot analysis of lysates from COS7 cells, treated with UV 30', using Tyrosinase Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of COS7 cells using TYR Polyclonal Antibody. Secondary antibody was diluted at 1:20000
  • Western blot analysis of various cell Lysate, antibody was diluted at 1:1000. Secondary antibody was diluted at 1:20000
  • Western blot analysis of various cells using TYR Polyclonal Antibody. Secondary antibody was diluted at 1:20000

Anti-TYR antibody (471-520 aa) (STJ96157)

SKU:
STJ96157

£48.00 - £252.00
Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Monkey
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Tyrosinase (471-520 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TYR
Gene ID: 7299
Uniprot ID: TYRO_HUMAN
Immunogen Region: 471-520 aa
Specificity: TYR Polyclonal Antibody detects endogenous levels of TYR protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human Tyrosinase at the amino acid range 471-520
Function This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.
Protein Name Tyrosinase
Lb24-Ab
Monophenol Monooxygenase
Sk29-Ab
Tumor Rejection Antigen Ab
Database Links Reactome: R-HSA-5662702
Reactome: R-HSA-9824585
Cellular Localisation Melanosome Membrane
Single-Pass Type I Membrane Protein
Melanosome
Proper Trafficking To Melanosome Is Regulated By Sgsm2
Ankrd27
Rab9a
Rab32 And Rab38
Alternative Antibody Names Anti-Tyrosinase antibody
Anti-Lb24-Ab antibody
Anti-Monophenol Monooxygenase antibody
Anti-Sk29-Ab antibody
Anti-Tumor Rejection Antigen Ab antibody
Anti-TYR antibody

Information sourced from Uniprot.org

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