| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TWF1 |
| Gene ID: | 5756 |
| Uniprot ID: | TWF1_HUMAN |
| Immunogen Region: | 101-350 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 101-350 of human TWF1 (NP_002813.3). |
| Immunogen Sequence: | YAATRATLKKEFGGGHIKDE VFGTVKEDVSLHGYKKYLLS QSSPAPLTAAEEELRQIKIN EVQTDVGVDTKHQTLQGVAF PISREAFQALEKLNNRQLNY VQLEIDIKNEIIILANTTNT ELKDLPKRIPKDSARYHFFL YKHSHEGDYLESIVFIYSMP GYTCSIRERMLYSSCKSRLL EIVERQLQMDVIRKIEIDNG DELTADFLYEEVHPKQHAHK QSFAKPKGPAGKRGIRRLI |
| Tissue Specificity | Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver. |
| Post Translational Modifications | Phosphorylated on serine and threonine residues. |
| Function | Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. |
| Protein Name | Twinfilin-1Protein A6Protein Tyrosine Kinase 9 |
| Database Links | Reactome: R-HSA-9013418Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | CytoplasmCytoskeletonDiffuse Cytoplasmic Localization With Perinuclear And G-Actin-Rich Cortical Actin Structures SublocalizationAlso Found At Membrane Ruffles And Cell-Cell Contacts |
| Alternative Antibody Names | Anti-Twinfilin-1 antibodyAnti-Protein A6 antibodyAnti-Protein Tyrosine Kinase 9 antibodyAnti-TWF1 antibodyAnti-PTK9 antibody |
Information sourced from Uniprot.org