| Tissue Specificity | Expressed in most non-lymphoid cells and tissues examined, including prostate, lung, liver, colon, heart, kidney and pancreas. |
| Function | Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues.in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Also has oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition. Could indirectly play a role in Mg(2+) transport. |
| Protein Name | Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit Tusc3Oligosaccharyl Transferase Subunit Tusc3Magnesium Uptake/Transporter Tusc3Protein N33Tumor Suppressor Candidate 3 |
| Database Links | Reactome: R-HSA-446203Reactome: R-HSA-5223345Reactome: R-HSA-9694548 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit Tusc3 antibodyAnti-Oligosaccharyl Transferase Subunit Tusc3 antibodyAnti-Magnesium Uptake/Transporter Tusc3 antibodyAnti-Protein N33 antibodyAnti-Tumor Suppressor Candidate 3 antibodyAnti-TUSC3 antibodyAnti-N33 antibody |
Information sourced from Uniprot.org
