Anti-TUSC3 antibody (131-180) (STJ94326)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human TUSC3. AA range:131-180
General Information
| Short Description | Rabbit polyclonal anti-Tumor suppressor candidate 3 (131-180) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TUSC3 |
| Gene ID | 7991 |
| Uniprot ID | TUSC3_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TUSC3. AA range:131-180 |
| Immunogen Region | 131-180 |
| Specificity | N33 Polyclonal Antibody detects endogenous levels of N33 protein. |
Additional Info
| Tissue Specificity | Expressed in most non-lymphoid cells and tissues examined, including prostate, lung, liver, colon, heart, kidney and pancreas. |
| Function | Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues.in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Also has oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition. Could indirectly play a role in Mg(2+) transport. |
| Protein Name | Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit Tusc3Oligosaccharyl Transferase Subunit Tusc3Magnesium Uptake/Transporter Tusc3Protein N33Tumor Suppressor Candidate 3 |
| Database Links | Reactome: R-HSA-446203Reactome: R-HSA-5223345Reactome: R-HSA-9694548 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit Tusc3 antibodyAnti-Oligosaccharyl Transferase Subunit Tusc3 antibodyAnti-Magnesium Uptake/Transporter Tusc3 antibodyAnti-Protein N33 antibodyAnti-Tumor Suppressor Candidate 3 antibodyAnti-TUSC3 antibodyAnti-N33 antibody |
Information sourced from Uniprot.org