| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TTC3 |
| Gene ID: |
7267 |
| Uniprot ID: |
TTC3_HUMAN |
| Immunogen Region: |
1400-1700 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1400-1700 of human TTC3 (NP_003307.3). |
| Immunogen Sequence: |
IASETQILEGSLGISVKSHC STGDAHTVLSESNRNDEHCG NSNNKCEVIPESTSAVTNIP HVQMVAIQVSWNIIHQEVNT EPYNPFEERQGEISRIEKEH QVLQDQLQEVYENYEQIKLK GLEETRDLEEKLKRHLEENK ISKTELDWFLQDLEREIKKW QQEKKEIQERLKSLKKKIKK VSNASEMYTQKNDGKEKEHE LHLDQSLEISNTLTNEKMKI EEYIKKGKEDYEESHQRAV |
| Tissue Specificity | Found in all tissues examined. |
| Post Translational Modifications | Phosphorylation on Ser-378 by Akt is required for ubiquitin ligase activity. Proteolytically cleaved into differently sized N- and C-terminal fragments. |
| Function | E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains. Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation.its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2. Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK. Inhibits cell proliferation. |
| Protein Name | E3 Ubiquitin-Protein Ligase Ttc3Protein Dcrr1Ring Finger Protein 105Ring-Type E3 Ubiquitin Transferase Ttc3Tpr Repeat Protein DTetratricopeptide Repeat Protein 3Tpr Repeat Protein 3 |
| Cellular Localisation | NucleusCytoplasmGolgi ApparatusNuclear Localization May Be Dependent On The Proteolytic Cleavage Of Full Length Protein In The CytoplasmThis Cleavage May Reveal An N-Terminal Nuclear Localization SignalAllowing N-Terminal Fragments To Enter The Nucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Ttc3 antibodyAnti-Protein Dcrr1 antibodyAnti-Ring Finger Protein 105 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Ttc3 antibodyAnti-Tpr Repeat Protein D antibodyAnti-Tetratricopeptide Repeat Protein 3 antibodyAnti-Tpr Repeat Protein 3 antibodyAnti-TTC3 antibodyAnti-DCRR1 antibodyAnti-RNF105 antibodyAnti-TPRD antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
