| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TSN |
| Gene ID: | 7247 |
| Uniprot ID: | TSN_HUMAN |
| Immunogen Region: | 50-150 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human TSN (NP_004613.1). |
| Immunogen Sequence: | GFQDIPKRCLKAREHFGTVK THLTSLKTKFPAEQYYRFHE HWRFVLQRLVFLAAFVVYLE TETLVTREAVTEILGIEPDR EKGFHLDVEDYLSGVLILAS E |
| Function | DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots. Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand. |
| Protein Name | TranslinComponent 3 Of Promoter Of RiscC3po |
| Database Links | Reactome: R-HSA-426486 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Translin antibodyAnti-Component 3 Of Promoter Of Risc antibodyAnti-C3po antibodyAnti-TSN antibody |
Information sourced from Uniprot.org