| Function | Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation and thereby NFKB1 DNA-binding activities. In vitro, suppresses AP-1 transcription factor complex DNA-binding activities. Isoform 1: Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG. |
| Protein Name | Tsc22 Domain Family Protein 3Dsip-Immunoreactive PeptideProtein DipHdipDelta Sleep-Inducing Peptide ImmunoreactorGlucocorticoid-Induced Leucine Zipper ProteinGilzTsc-22-Like ProteinTsc-22-Related ProteinTsc-22r |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Isoform 1: CytoplasmNucleusLocalization Depends On Differentiation Status Of MyoblastsIn Undifferentiated MyoblastsLocalizes To The CytoplasmBut In Differentiating MyoblastLocalizes To The Nucleus |
| Alternative Antibody Names | Anti-Tsc22 Domain Family Protein 3 antibodyAnti-Dsip-Immunoreactive Peptide antibodyAnti-Protein Dip antibodyAnti-Hdip antibodyAnti-Delta Sleep-Inducing Peptide Immunoreactor antibodyAnti-Glucocorticoid-Induced Leucine Zipper Protein antibodyAnti-Gilz antibodyAnti-Tsc-22-Like Protein antibodyAnti-Tsc-22-Related Protein antibodyAnti-Tsc-22r antibodyAnti-TSC22D3 antibodyAnti-DSIPI antibodyAnti-GILZ antibody |
Information sourced from Uniprot.org
