| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRPV3 is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:500 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
TRPV3 |
| Gene ID: |
162514 |
| Uniprot ID: |
TRPV3_HUMAN |
| Specificity: |
Specific for TRPV3. |
| Immunogen: |
A synthetic peptide from human TRPV3 conjugated to blue carrier protein was used as the antigen. |
| Function | Receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen). |
| Protein Name | Transient Receptor Potential Cation Channel Subfamily V Member 3Trpv3Vanilloid Receptor-Like 3Vrl-3 |
| Database Links | Reactome: R-HSA-3295583 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmLysosomeTargeted To Lysosome For Degradation In A Snx11-Dependent Manner |
| Alternative Antibody Names | Anti-Transient Receptor Potential Cation Channel Subfamily V Member 3 antibodyAnti-Trpv3 antibodyAnti-Vanilloid Receptor-Like 3 antibodyAnti-Vrl-3 antibodyAnti-TRPV3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
