• Western blot analysis of lysates from A431 cells, primary antibody was diluted at 1:1000, 4°C over night

Anti-TRPM2 antibody (41-91 aa) (STJ194030)

SKU:
STJ194030

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Transient receptor potential cation channel subfamily M member 2 (41-91 aa) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TRPM2
Gene ID: 7226
Uniprot ID: TRPM2_HUMAN
Immunogen Region: 41-91 aa
Specificity: This antibody detects endogenous levels of TRPM2 at Human/Mouse
Immunogen: Synthesized peptide derived from the human TRPM2 at the amino acid range 41-91
Function Isoform 1: Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels. Functions as ligand-gated ion channel. Binding of ADP-ribose to the cytoplasmic Nudix domain causes a conformation change.the channel is primed but still requires Ca(2+) binding to trigger channel opening. Extracellular calcium passes through the channel and increases channel activity. Contributes to Ca(2+) release from intracellular stores in response to ADP-ribose. Plays a role in numerous processes that involve signaling via intracellular Ca(2+) levels (Probable). Besides, mediates the release of lysosomal Zn(2+) stores in response to reactive oxygen species, leading to increased cytosolic Zn(2+) levels. Activated by moderate heat (35 to 40 degrees Celsius). Activated by intracellular ADP-ribose, beta-NAD (NAD(+)) and similar compounds, and by oxidative stress caused by reactive oxygen or nitrogen species. The precise physiological activators are under debate.the true, physiological activators may be ADP-ribose and ADP-ribose-2'-phosphate. Activation by ADP-ribose and beta-NAD is strongly increased by moderate heat (35 to 40 degrees Celsius). Likewise, reactive oxygen species lower the threshold for activation by moderate heat (37 degrees Celsius). Plays a role in mediating behavorial and physiological responses to moderate heat and thereby contributes to body temperature homeostasis. Plays a role in insulin secretion, a process that requires increased cytoplasmic Ca(2+) levels. Required for normal IFNG and cytokine secretion and normal innate immune immunity in response to bacterial infection. Required for normal phagocytosis and cytokine release by macrophages exposed to zymosan (in vitro). Plays a role in dendritic cell differentiation and maturation, and in dendritic cell chemotaxis via its role in regulating cytoplasmic Ca(2+) levels. Plays a role in the regulation of the reorganization of the actin cytoskeleton and filopodia formation in response to reactive oxygen species via its role in increasing cytoplasmic Ca(2+) and Zn(2+) levels. Confers susceptibility to cell death following oxidative stress. Isoform 2: Lacks cation channel activity. Does not mediate cation transport in response to oxidative stress or ADP-ribose. Isoform 3: Lacks cation channel activity and negatively regulates the channel activity of isoform 1. Negatively regulates susceptibility to cell death in reposponse to oxidative stress.
Protein Name Transient Receptor Potential Cation Channel Subfamily M Member 2
Estrogen-Responsive Element-Associated Gene 1 Protein
Long Transient Receptor Potential Channel 2
Ltrpc-2
Ltrpc2
Transient Receptor Potential Channel 7
Trpc7
Transient Receptor Potential Melastatin 2
Database Links Reactome: R-HSA-3295583
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Perikaryon
Cell Projection
Cytoplasmic Vesicle
Lysosome
Detected At The Cell Membrane And In Intracellular Vesicles In Cortical Neurons
Detected On Neuronal Cell Bodies And Neurites
Detected On The Cell Membrane In Polymorphonuclear Neutrophils
Detected On Cytoplasmic Vesicles And Lysosomes In Immature Bone Marrow Dendritic Cells
Isoform 1: Cell Membrane
Isoform 2: Cell Membrane
Isoform 3: Cell Membrane
Alternative Antibody Names Anti-Transient Receptor Potential Cation Channel Subfamily M Member 2 antibody
Anti-Estrogen-Responsive Element-Associated Gene 1 Protein antibody
Anti-Long Transient Receptor Potential Channel 2 antibody
Anti-Ltrpc-2 antibody
Anti-Ltrpc2 antibody
Anti-Transient Receptor Potential Channel 7 antibody
Anti-Trpc7 antibody
Anti-Transient Receptor Potential Melastatin 2 antibody
Anti-TRPM2 antibody
Anti-EREG1 antibody
Anti-KNP3 antibody
Anti-LTRPC2 antibody
Anti-TRPC7 antibody

Information sourced from Uniprot.org

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