| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TRPC5 |
| Gene ID: | 7224 |
| Uniprot ID: | TRPC5_HUMAN |
| Immunogen Region: | 800-900 |
| Immunogen Sequence: | NLGCKKKTCHGPPLIRTMPR SSGAQGKSKAESSSKRSFMG PSLKKLGLLFSKFNGHMSEP SSEPMYTISDGIVQQHCMWQ DIRYSQMEKGKAEACSQSEI N |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 800-900 of human TRPC5 (NP_036603.1). |
| Tissue Specificity | Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole. |
| Function | Forms a receptor-activated non-selective calcium permeant cation channel. Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1. Acts on distinct neuronal populations in the hypothalamus to regulate innate behaviors including feeding, anxiety (flight/fight/fear), socialization, and maternal care. |
| Protein Name | Short Transient Receptor Potential Channel 5Trpc5Transient Receptor Protein 5Trp-5Htrp-5Htrp5 |
| Database Links | Reactome: R-HSA-3295583Reactome: R-HSA-418890 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Short Transient Receptor Potential Channel 5 antibodyAnti-Trpc5 antibodyAnti-Transient Receptor Protein 5 antibodyAnti-Trp-5 antibodyAnti-Htrp-5 antibodyAnti-Htrp5 antibodyAnti-TRPC5 antibodyAnti-TRP5 antibody |
Information sourced from Uniprot.org
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