| Host: | Sheep |
| Applications: | IHC/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Sheep polyclonal antibody anti-TRPC5 (4th Cytoplasmic Domain) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | TRPC5 |
| Gene ID: | 7224 |
| Uniprot ID: | TRPC5_HUMAN |
| Immunogen Region: | 4th Cytoplasmic Domain |
| Specificity: | Specific for TRPC5. |
| Immunogen: | A synthetic peptide from 4th cytoplasmic domain of human TRPC5 (TRP5) conjugated to an immunogenic carrier protein was used as the immunogen. |
| Function | Forms a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion. Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1. Acts on distinct neuronal populations in the hypothalamus to regulate innate behaviors including feeding, anxiety (flight/fight/fear), socialization, and maternal care. |
| Protein Name | Short Transient Receptor Potential Channel 5Trpc5Transient Receptor Protein 5Trp-5Htrp-5Htrp5 |
| Database Links | Reactome: R-HSA-3295583Reactome: R-HSA-418890 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Short Transient Receptor Potential Channel 5 antibodyAnti-Trpc5 antibodyAnti-Transient Receptor Protein 5 antibodyAnti-Trp-5 antibodyAnti-Htrp-5 antibodyAnti-Htrp5 antibodyAnti-TRPC5 antibodyAnti-TRP5 antibody |
Information sourced from Uniprot.org