Anti-TRPC4 antibody (4th Cytoplasmic Loop) (STJ13102426)

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STJ13102426-100
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Short Description :Rabbit polyclonal anti-TRPC4 (4th Cytoplasmic Loop) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:IHC/WB
Host:Rabbit
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Polyclonal
Isotype:IgG
Conjugation:Unconjugated
Purification:IgG purified
Dilution Range:IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user.
Formulation:Lyophilised
Storage Instruction:Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol:TRPC4
Gene ID:7223
Uniprot ID:TRPC4_HUMAN
Immunogen:A synthetic peptide from the 4th cytoplasmic loop of human TRPC4 (TRP4; alpha, beta, gamma isoforms) conjugated to an immunogenic carrier protein was used as the antigen.
Immunogen Region:4th Cytoplasmic Loop
Specificity:Specific for TRPC4.
Post Translational Modifications Phosphorylation modulates TRPC channel function by regulating the level of TRPC4 at the cell surface and by increasing the association with NHERF1.
Function Forms a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Forms a homomeric ion channel or a heteromeric ion channel with TRPC1.the heteromeric ion channel has reduced calcium permeability compared to the homomeric channel. Also permeable to monovalent ions including sodium, lithium and cesium ions. Isoform Beta: Forms a receptor-activated non-selective calcium permeant cation channel.
Protein Name Short Transient Receptor Potential Channel 4
Trpc4
Trp-Related Protein 4
Htrp-4
Htrp4
Database Links Reactome: R-HSA-3295583
Reactome: R-HSA-418890
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Enhanced Insertion Into The Cell Membrane After Activation Of The Egf Receptor
Isoform Beta: Cell Membrane
Alternative Antibody Names Anti-Short Transient Receptor Potential Channel 4 antibody
Anti-Trpc4 antibody
Anti-Trp-Related Protein 4 antibody
Anti-Htrp-4 antibody
Anti-Htrp4 antibody
Anti-TRPC4 antibody

Information sourced from Uniprot.org

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