Anti-TRPC4 antibody (4th Cytoplasmic Loop) (STJ13102426)

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STJ13102426-100
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Host: Rabbit
Applications: IHC/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-TRPC4 (4th Cytoplasmic Loop) is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Lyophilised
Purification: IgG purified
Dilution Range: IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user.
Storage Instruction: Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol: TRPC4
Gene ID: 7223
Uniprot ID: TRPC4_HUMAN
Immunogen Region: 4th Cytoplasmic Loop
Specificity: Specific for TRPC4.
Immunogen: A synthetic peptide from the 4th cytoplasmic loop of human TRPC4 (TRP4; alpha, beta, gamma isoforms) conjugated to an immunogenic carrier protein was used as the antigen.
Post Translational Modifications Phosphorylation modulates TRPC channel function by regulating the level of TRPC4 at the cell surface and by increasing the association with NHERF1.
Function Forms a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. May also be activated by intracellular calcium store depletion. Isoform Beta: Forms a receptor-activated non-selective calcium permeant cation channel.
Protein Name Short Transient Receptor Potential Channel 4
Trpc4
Trp-Related Protein 4
Htrp-4
Htrp4
Database Links Reactome: R-HSA-3295583
Reactome: R-HSA-418890
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Enhanced Insertion Into The Cell Membrane After Activation Of The Egf Receptor
Isoform Beta: Cell Membrane
Alternative Antibody Names Anti-Short Transient Receptor Potential Channel 4 antibody
Anti-Trpc4 antibody
Anti-Trp-Related Protein 4 antibody
Anti-Htrp-4 antibody
Anti-Htrp4 antibody
Anti-TRPC4 antibody

Information sourced from Uniprot.org

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