| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRMT112 (1-125) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRMT112 |
| Gene ID: |
51504 |
| Uniprot ID: |
TR112_HUMAN |
| Immunogen Region: |
1-125 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-125 of human TRMT112 (NP_057488.1). |
| Immunogen Sequence: |
MKLLTHNLLSSHVRGVGSRG FPLRLQATEVRICPVEFNPN FVARMIPKVEWSAFLEAADN LRLIQVPKGPVEGYEENEEF LRTMHHLLLEVEVIEGTLQC PESGRMFPISRGIPNMLLSE EETES |
| Function | Acts as an activator of both rRNA/tRNA and protein methyltransferases. Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA. The heterodimer with N6AMT1/HEMK2 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. The heterodimer with N6AMT1/HEMK2 also monomethylates 'Lys-12' of histone H4 (H4K12me1). The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species. Together with methyltransferase THUMPD3, catalyzes the formation of N(2)-methylguanosine at position 6 in a broad range of tRNA substrates and at position 7 of tRNA(Trp). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production. Together with methyltransferase METTL5, specifically methylates the 6th position of adenine in position 1832 of 18S rRNA. |
| Protein Name | Multifunctional Methyltransferase Subunit Trm112-Like ProteinTrna Methyltransferase 112 Homolog |
| Database Links | Reactome: R-HSA-156581Reactome: R-HSA-6782315Reactome: R-HSA-6790901Reactome: R-HSA-72764 |
| Cellular Localisation | NucleusNucleoplasmCytoplasmPerinuclear RegionLocalizes To A Polarized Perinuclear StructureOverlapping Partially With The Golgi And Lysosomes |
| Alternative Antibody Names | Anti-Multifunctional Methyltransferase Subunit Trm112-Like Protein antibodyAnti-Trna Methyltransferase 112 Homolog antibodyAnti-TRMT112 antibodyAnti-AD-001 antibodyAnti-HSPC152 antibodyAnti-HSPC170 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
