| Function | Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes. Plays a role in mitotic spindle assembly checkpoint (SAC) activation. |
| Protein Name | Pachytene Checkpoint Protein 2 HomologHuman Papillomavirus Type 16 E1 Protein-Binding Protein16e1-BpHpv16 E1 Protein-Binding ProteinThyroid Hormone Receptor Interactor 13Thyroid Receptor-Interacting Protein 13Tr-Interacting Protein 13Trip-13 |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Pachytene Checkpoint Protein 2 Homolog antibodyAnti-Human Papillomavirus Type 16 E1 Protein-Binding Protein antibodyAnti-16e1-Bp antibodyAnti-Hpv16 E1 Protein-Binding Protein antibodyAnti-Thyroid Hormone Receptor Interactor 13 antibodyAnti-Thyroid Receptor-Interacting Protein 13 antibodyAnti-Tr-Interacting Protein 13 antibodyAnti-Trip-13 antibodyAnti-TRIP13 antibodyAnti-PCH2 antibody |
Information sourced from Uniprot.org
