| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRIOBP (180-310) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRIOBP |
| Gene ID: |
11078 |
| Uniprot ID: |
TARA_HUMAN |
| Immunogen Region: |
180-310 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 180-310 of human TRIOBP (NP_008963.3). |
| Immunogen Sequence: |
DVTKLSDSNKENALHSYSTQ KGPLKAGEQRAGSEVISRGG PRKADGQRQALDYVELSPLT QASPQRARTPARTPDRLAKQ EELERDLAQRSEERRKWFEA TDSRTPEVPAGEGPRRGLGA PLTEDQQNRLS |
| Tissue Specificity | Isoform 1: Widely expressed. Highly expressed in heart and placenta. Isoform 3: Expressed in fetal brain, retina and cochlea but is not detectable in the other tissues. |
| Post Translational Modifications | Isoform 1: Ubiquitinated by HECTD3, leading to its degradation by the proteasome. Isoform 1: Phosphorylation at Thr-457 by PLK1 ensures mitotic progression and is essential for accurate chromosome segregation. Phosphorylation at residues Thr-221 and Thr-457 by kinase NEK2A and PLK1 coordinates TERF1 translocation from telomere to spindle pole. |
| Function | Isoform 1: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover. Essential for correct mitotic progression. Isoform 5: Plays a pivotal role in the formation of stereocilia rootlets. Isoform 4: Plays a pivotal role in the formation of stereocilia rootlets. |
| Protein Name | Trio And F-Actin-Binding ProteinProtein TaraTrf1-Associated Protein Of 68 KdaTrio-Associated Repeat On Actin |
| Database Links | Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | NucleusIsoform 1: NucleusCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeMidbodyChromosomeTelomereCentrosomal Localization Occurs Upon Phosphorylation By Plk1 At Thr-457 And Lasts From Prophase To AnaphaseAt TelophaseRelocalizes To Midbody |
| Alternative Antibody Names | Anti-Trio And F-Actin-Binding Protein antibodyAnti-Protein Tara antibodyAnti-Trf1-Associated Protein Of 68 Kda antibodyAnti-Trio-Associated Repeat On Actin antibodyAnti-TRIOBP antibodyAnti-KIAA1662 antibodyAnti-TARA antibodyAnti-HRIHFB2122 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
