| Tissue Specificity | Isoform 1: Widely expressed. Highly expressed in heart and placenta. Isoform 3: Expressed in fetal brain, retina and cochlea but is not detectable in the other tissues. |
| Post Translational Modifications | Isoform 1: Ubiquitinated by HECTD3, leading to its degradation by the proteasome. Isoform 1: Phosphorylation at Thr-457 by PLK1 ensures mitotic progression and is essential for accurate chromosome segregation. Phosphorylation at residues Thr-221 and Thr-457 by kinase NEK2A and PLK1 coordinates TERF1 translocation from telomere to spindle pole. |
| Function | Isoform 1: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover. Essential for correct mitotic progression. Isoform 5: Plays a pivotal role in the formation of stereocilia rootlets. Isoform 4: Plays a pivotal role in the formation of stereocilia rootlets. |
| Protein Name | Trio And F-Actin-Binding ProteinProtein TaraTrf1-Associated Protein Of 68 KdaTrio-Associated Repeat On Actin |
| Database Links | Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | NucleusIsoform 1: NucleusCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeMidbodyChromosomeTelomereCentrosomal Localization Occurs Upon Phosphorylation By Plk1 At Thr-457 And Lasts From Prophase To AnaphaseAt TelophaseRelocalizes To Midbody |
| Alternative Antibody Names | Anti-Trio And F-Actin-Binding Protein antibodyAnti-Protein Tara antibodyAnti-Trf1-Associated Protein Of 68 Kda antibodyAnti-Trio-Associated Repeat On Actin antibodyAnti-TRIOBP antibodyAnti-KIAA1662 antibodyAnti-TARA antibodyAnti-HRIHFB2122 antibody |
Information sourced from Uniprot.org
