Anti-TRIM59 antibody (1-330) (STJ115815)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TRIM59 (1-330) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TRIM59 |
| Gene ID | 286827 |
| Uniprot ID | TRI59_HUMAN |
| Immunogen Region | 1-330 |
| Immunogen Sequence | MHNFEEELTCPICYSIFEDP RVLPCSHTFCRNCLENILQA SGNFYIWRPLRIPLKCPNCR SITEIAPTGIESLPVNFALR AIIEKYQQEDHPDIVTCPEH YRQPLNVYCLLDKKLVCGHC LTIGQHHGHPIDDLQSAYLK EKDTPQKLLEQLTDTHWTDL THLIEKLKEQKSHSEKMIQG DKEAVLQYFKELNDTLEQKK KSFLTALCDVGNLINQEYTP QIERMKEIREQQLELMALT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-330 of human TRIM59 (NP_775107.1). |
Additional Info
| Function | E3 ubiquitin ligase involved in different processes such as development and immune response. Serves as a negative regulator for innate immune signaling pathways by suppressing RLR-induced activation of IRF3/7 and NF-kappa-B via interaction with adapter ECSIT. Regulates autophagy through modulating both the transcription and the ubiquitination of BECN1. On the one hand, regulates the transcription of BECN1 through negatively modulating the NF-kappa-B pathway. On the other hand, regulates TRAF6-mediated 'Lys-63'-linked ubiquitination of BECN1, thus affecting the formation of the BECN1-PIK3C3 complex. In addition, mediates 'Lys-48'-linked ubiquitination of TRAF6 and thereby promotes TRAF6 proteasomal degradation. Also acts as a critical regulator for early embryo development from blastocyst stage to gastrula through modulating F-actin assembly and WASH1 'Lys-63'-linked ubiquitination. |
| Protein Name | Tripartite Motif-Containing Protein 59Ring Finger Protein 104Tumor Suppressor Tsbf-1 |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Tripartite Motif-Containing Protein 59 antibodyAnti-Ring Finger Protein 104 antibodyAnti-Tumor Suppressor Tsbf-1 antibodyAnti-TRIM59 antibodyAnti-RNF104 antibodyAnti-TRIM57 antibodyAnti-TSBF1 antibody |
Information sourced from Uniprot.org