| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRIM59 (1-330) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRIM59 |
| Gene ID: |
286827 |
| Uniprot ID: |
TRI59_HUMAN |
| Immunogen Region: |
1-330 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-330 of human TRIM59 (NP_775107.1). |
| Immunogen Sequence: |
MHNFEEELTCPICYSIFEDP RVLPCSHTFCRNCLENILQA SGNFYIWRPLRIPLKCPNCR SITEIAPTGIESLPVNFALR AIIEKYQQEDHPDIVTCPEH YRQPLNVYCLLDKKLVCGHC LTIGQHHGHPIDDLQSAYLK EKDTPQKLLEQLTDTHWTDL THLIEKLKEQKSHSEKMIQG DKEAVLQYFKELNDTLEQKK KSFLTALCDVGNLINQEYTP QIERMKEIREQQLELMALT |
| Function | E3 ubiquitin ligase involved in different processes such as development and immune response. Serves as a negative regulator for innate immune signaling pathways by suppressing RLR-induced activation of IRF3/7 and NF-kappa-B via interaction with adapter ECSIT. Regulates autophagy through modulating both the transcription and the ubiquitination of BECN1. On the one hand, regulates the transcription of BECN1 through negatively modulating the NF-kappa-B pathway. On the other hand, regulates TRAF6-mediated 'Lys-63'-linked ubiquitination of BECN1, thus affecting the formation of the BECN1-PIK3C3 complex. In addition, mediates 'Lys-48'-linked ubiquitination of TRAF6 and thereby promotes TRAF6 proteasomal degradation. Acts also as a critical regulator for early embryo development from blastocyst stage to gastrula through modulating F-actin assembly and WASH1 'Lys-63'-linked ubiquitination. |
| Protein Name | Tripartite Motif-Containing Protein 59Ring Finger Protein 104Tumor Suppressor Tsbf-1 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Tripartite Motif-Containing Protein 59 antibodyAnti-Ring Finger Protein 104 antibodyAnti-Tumor Suppressor Tsbf-1 antibodyAnti-TRIM59 antibodyAnti-RNF104 antibodyAnti-TRIM57 antibodyAnti-TSBF1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
