Anti-TRIM41 antibody (421-630) (STJ26386)

Name: Anti-TRIM41 antibody (421-630) (STJ26386)
SKU: STJ26386
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ26386

Current Stock:

🚚 Free UK Delivery on orders over £150

Quantity:

Processing The item has been added

Enquire For Bulk Order

✓ 1-Year Performance Guarantee | SDS & Datasheet Included | Expert Tech Support | Covered by St John's Laboratory Guarantee

Short Description	Rabbit polyclonal TRIM41 (421-630) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	TRIM41
Gene ID	90933
Uniprot ID	TRI41_HUMAN
Immunogen Region	421-630
Immunogen Sequence	MSRMFCQAARVDLTLDPDTA HPALMLSPDRRGVRLAERRQ EVADHPKRFSADCCVLGAQG FRSGRHYWEVEVGGRRGWAV GAARESTHHKEKVGPGGSSV GSGDASSSRHHHRRRRLHLP QQPLLQREVWCVGTNGKRYQ AQSSTEQTLLSPSEKPRRFG VYLDYEAGRLGFYNAETLAH VHTFSAAFLGERVFPFFRVL SKGTRIKLCP
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 421-630 of human TRIM41 (NP_291027.3).

Tissue Specificity	Expressed in multiple tissues with the highest levels in heart and skeletal muscle.
Post Translational Modifications	Auto-ubiquitinated.
Function	E3 ligase that plays essential roles in innate antiviral response. Directly binds to influenza A virus or vesicular stomatitis virus nucleoproteins and targets them for ubiquitination and proteasomal degradation, thereby limiting viral infections. Activates the innate antiviral response by catalyzing monoubiquitination of CGAS, thereby activating CGAS. Also involved in innate antiviral response by mediating 'Lys-63'-linked polyubiquitylation of BCL10 which in turn hubs NEMO for activation of NF-kappa-B and IRF3 pathways. Catalyzes the ubiquitin-mediated degradation of other substrates including protein kinase C, ZSCAN21 or TOP3B suggesting additional roles besides its function in immune response.
Protein Name	E3 Ubiquitin-Protein Ligase Trim41 Ring Finger-Interacting Protein With C Kinase Rinck Tripartite Motif-Containing Protein 41
Database Links	Reactome: R-HSA-983168
Cellular Localisation	Cytoplasm Nucleus
Alternative Antibody Names	Anti-E3 Ubiquitin-Protein Ligase Trim41 antibody Anti-Ring Finger-Interacting Protein With C Kinase antibody Anti-Rinck antibody Anti-Tripartite Motif-Containing Protein 41 antibody Anti-TRIM41 antibody Anti-RINCK antibody

Information sourced from Uniprot.org