| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TRIM29 |
| Gene ID: | 23650 |
| Uniprot ID: | TRI29_HUMAN |
| Immunogen Region: | 309-588 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 309-588 of human TRIM29 (NP_036233.2). |
| Immunogen Sequence: | ILEQNFRDLVRDLEKQKEEV RAALEQREQDAVDQVKVIMD ALDERAKVLHEDKQTREQLH SISDSVLFLQEFGALMSNYS LPPPLPTYHVLLEGEGLGQS LGNFKDDLLNVCMRHVEKMC KADLSRNFIERNHMENGGDH RYVNNYTNSFGGEWSAPDTM KRYSMYLTPKGGVRTSYQPS SPGRFTKETTQKNFNNLYGT KGNYTSRVWEYSSSIQNSDN DLPVVQGSSSFSLKGYPSL |
| Tissue Specificity | Expressed in placenta, prostate and thymus. |
| Post Translational Modifications | Constitutively phosphorylated by PKC on serine/threonine in A431 cells. |
| Function | Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation. |
| Protein Name | Tripartite Motif-Containing Protein 29Ataxia Telangiectasia Group D-Associated Protein |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | CytoplasmLysosomeColocalizes With Intermediate Filaments |
| Alternative Antibody Names | Anti-Tripartite Motif-Containing Protein 29 antibodyAnti-Ataxia Telangiectasia Group D-Associated Protein antibodyAnti-TRIM29 antibodyAnti-ATDC antibody |
Information sourced from Uniprot.org