| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRIM29 (309-588) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRIM29 |
| Gene ID: |
23650 |
| Uniprot ID: |
TRI29_HUMAN |
| Immunogen Region: |
309-588 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 309-588 of human TRIM29 (NP_036233.2). |
| Immunogen Sequence: |
ILEQNFRDLVRDLEKQKEEV RAALEQREQDAVDQVKVIMD ALDERAKVLHEDKQTREQLH SISDSVLFLQEFGALMSNYS LPPPLPTYHVLLEGEGLGQS LGNFKDDLLNVCMRHVEKMC KADLSRNFIERNHMENGGDH RYVNNYTNSFGGEWSAPDTM KRYSMYLTPKGGVRTSYQPS SPGRFTKETTQKNFNNLYGT KGNYTSRVWEYSSSIQNSDN DLPVVQGSSSFSLKGYPSL |
| Tissue Specificity | Expressed in placenta, prostate and thymus. |
| Post Translational Modifications | Constitutively phosphorylated by PKC on serine/threonine in A431 cells. |
| Function | Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation. |
| Protein Name | Tripartite Motif-Containing Protein 29Ataxia Telangiectasia Group D-Associated Protein |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | CytoplasmLysosomeColocalizes With Intermediate Filaments |
| Alternative Antibody Names | Anti-Tripartite Motif-Containing Protein 29 antibodyAnti-Ataxia Telangiectasia Group D-Associated Protein antibodyAnti-TRIM29 antibodyAnti-ATDC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
