Anti-TRIM16 antibody (31-80 aa) (STJ96100)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human TRIM16 at the amino acid range 31-80
General Information
| Short Description | Rabbit polyclonal anti-Tripartite motif-containing protein 16 (31-80 aa) for use in IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TRIM16 |
| Gene ID | 10626 |
| Uniprot ID | TRI16_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human TRIM16 at the amino acid range 31-80 |
| Immunogen Region | 31-80 aa |
| Specificity | TRIM16 Polyclonal Antibody detects endogenous levels of TRIM16 protein. |
Additional Info
| Post Translational Modifications | Phosphorylated by ULK1. Auto-ubiquitinates via its B-Boxes. |
| Function | E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage. |
| Protein Name | Tripartite Motif-Containing Protein 16E3 Ubiquitin-Protein Ligase Trim16Estrogen-Responsive B Box Protein |
| Database Links | |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Tripartite Motif-Containing Protein 16 antibodyAnti-E3 Ubiquitin-Protein Ligase Trim16 antibodyAnti-Estrogen-Responsive B Box Protein antibodyAnti-TRIM16 antibodyAnti-EBBP antibody |
Information sourced from Uniprot.org