| Tissue Specificity | Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow. |
| Function | Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase. The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain. Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA. Binds selectively the recognition sequence of CEBPA. Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner. Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain. Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity. |
| Protein Name | Tribbles Homolog 1Trb-1G-Protein-Coupled Receptor-Induced Gene 2 ProteinGig-2Skip1 |
| Database Links | Reactome: R-HSA-9031628 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Tribbles Homolog 1 antibodyAnti-Trb-1 antibodyAnti-G-Protein-Coupled Receptor-Induced Gene 2 Protein antibodyAnti-Gig-2 antibodyAnti-Skip1 antibodyAnti-TRIB1 antibodyAnti-C8FW antibodyAnti-GIG2 antibodyAnti-TRB1 antibody |
Information sourced from Uniprot.org
![Immunofluorescence analysis of U2OS cells using [KO Validated] macroH2A. 1 Rabbit polyclonal antibody (STJ29125). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/102323/391020/STJ29125_1__34622.1713161168.jpg?c=1 "Immunofluorescence analysis of U2OS cells using [KO Validated] macroH2A. 1 Rabbit polyclonal antibody (STJ29125). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.")
