| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | TRDN |
| Gene ID: | 10345 |
| Uniprot ID: | TRDN_HUMAN |
| Immunogen Region: | 1-101 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-101 of human TRDN (NP_001242949.1). |
| Immunogen Sequence: | MTEITAEGNASTTTTVIDSK NGSVPKSPGKVLKRTVTEDI VTTFSSPAAWLLVIALIITW SAVAIVMFDLVDYKNFSASS IAKIGSDPLKLVRDAMEETT D |
| Post Translational Modifications | Phosphorylated by CaMK2. N-glycosylated. |
| Function | Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. |
| Protein Name | Triadin |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-5578775 |
| Cellular Localisation | Cell MembraneSarcoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Triadin antibodyAnti-TRDN antibody |
Information sourced from Uniprot.org
