| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S7MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:6000 IHC-P:1:100-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TF |
| Gene ID: | 7018 |
| Uniprot ID: | TRFE_HUMAN |
| Immunogen Region: | 50-150 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Transferrin (P02787). |
| Immunogen Sequence: | PSDGPSVACVKKASYLDCIR AIAANEADAVTLDAGLVYDA YLAPNNLKPVVAEFYGSKED PQTFYYAVAVVKKDSGFQMN QLRGKKSCHTGLGRSAGWNI P |
| Tissue Specificity | Expressed by the liver and secreted in plasma. |
| Function | Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. (Microbial infection) Serves as an iron source for Neisseria species, which capture the protein and extract its iron for their own use. (Microbial infection) Serves as an iron source for parasite T.brucei (strain 427), which capture TF via its own transferrin receptor ESAG6:ESAG7 and extract its iron for its own use. |
| Protein Name | Serotransferrin Transferrin Beta-1 Metal-Binding Globulin Siderophilin |
| Database Links | Reactome: R-HSA-114608 Reactome: R-HSA-381426 Reactome: R-HSA-8856825 Reactome: R-HSA-8856828 Reactome: R-HSA-8957275 Reactome: R-HSA-917937 Reactome: R-HSA-917977 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Serotransferrin antibody Anti-Transferrin antibody Anti-Beta-1 Metal-Binding Globulin antibody Anti-Siderophilin antibody Anti-TF antibody Anti-PRO1400 antibody |
Information sourced from Uniprot.org