| Tissue Specificity | Widely expressed. |
| Function | Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification. |
| Protein Name | Ekc/Keops Complex Subunit TprkbPrpk-Binding ProteinTp53rk-Binding Protein |
| Database Links | Reactome: R-HSA-6782315 |
| Cellular Localisation | CytoplasmCytosolNucleus |
| Alternative Antibody Names | Anti-Ekc/Keops Complex Subunit Tprkb antibodyAnti-Prpk-Binding Protein antibodyAnti-Tp53rk-Binding Protein antibodyAnti-TPRKB antibodyAnti-CGI-121 antibodyAnti-My019 antibody |
Information sourced from Uniprot.org