| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TPM3 |
| Gene ID: | 7170 |
| Uniprot ID: | TPM3_HUMAN |
| Immunogen Region: | 1-285 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-285 of human TPM3 (NP_689476.2). |
| Immunogen Sequence: | MMEAIKKKMQMLKLDKENAL DRAEQAEAEQKQAEERSKQL EDELAAMQKKLKGTEDELDK YSEALKDAQEKLELAEKKAA DAEAEVASLNRRIQLVEEEL DRAQERLATALQKLEEAEKA ADESERGMKVIENRALKDEE KMELQEIQLKEAKHIAEEAD RKYEEVARKLVIIEGDLERT EERAELAESKCSELEEELKN VTNNLKSLEAQAEKYSQKED KYEEEIKILTDKLKEAETR |
| Function | Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. |
| Protein Name | Tropomyosin Alpha-3 ChainGamma-TropomyosinTropomyosin-3Tropomyosin-5Htm5 |
| Database Links | Reactome: R-HSA-390522Reactome: R-HSA-445355Reactome: R-HSA-9013424Reactome: R-HSA-9725370 |
| Cellular Localisation | CytoplasmCytoskeleton |
| Alternative Antibody Names | Anti-Tropomyosin Alpha-3 Chain antibodyAnti-Gamma-Tropomyosin antibodyAnti-Tropomyosin-3 antibodyAnti-Tropomyosin-5 antibodyAnti-Htm5 antibodyAnti-TPM3 antibody |
Information sourced from Uniprot.org