| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TPK1 |
| Gene ID: |
27010 |
| Uniprot ID: |
TPK1_HUMAN |
| Immunogen Region: |
1-243 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-243 of human TPK1 (NP_071890.2). |
| Immunogen Sequence: |
MEHAFTPLEPLLSTGNLKYC LVILNQPLDNYFRHLWNKAL LRACADGGANRLYDITEGER ESFLPEFINGDFDSIRPEVR EYYATKGCELISTPDQDHTD FTKCLKMLQKKIEEKDLKVD VIVTLGGLAGRFDQIMASVN TLFQATHITPFPIIIIQEES LIYLLQPGKHRLHVDTGMEG DWCGLIPVGQPCMQVTTTGL KWNLTNDVLAFGTLVSTSNT YDGSGVVTVETDHPLLWTM |
| Tissue Specificity | Detected in heart, kidney, testis, small intestine and peripheral blood leukocytes, and at very low levels in a variety of tissues. |
| Function | Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate (TPP) utilizing UTP and therefore links the biosynthesis of TPP to pyrimidines metabolism. By producing thiamine pyrophosphate, a cofactor of the mitochondrial pyruvate dehydrogenase indirectly regulates pyruvate oxidation and lipogenesis. Although it can also catalyze thiamine phosphorylation using ATP and CTP in vitro, it does so with significantly lower efficiency and without physiological relevance evidence. |
| Protein Name | Thiamine Pyrophosphokinase 1Htpk1Placental Protein 20Pp20Thiamin Pyrophosphokinase 1 |
| Database Links | Reactome: R-HSA-196819 |
| Alternative Antibody Names | Anti-Thiamine Pyrophosphokinase 1 antibodyAnti-Htpk1 antibodyAnti-Placental Protein 20 antibodyAnti-Pp20 antibodyAnti-Thiamin Pyrophosphokinase 1 antibodyAnti-TPK1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
