Anti-TP53RK antibody (1-253) (STJ117151)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TP53RK (1-253) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TP53RK |
| Gene ID | 112858 |
| Uniprot ID | PRPK_HUMAN |
| Immunogen Region | 1-253 |
| Immunogen Sequence | MAAARATTPADGEEPAPEAE ALAAARERSSRFLSGLELVK QGAEARVFRGRFQGRAAVIK HRFPKGYRHPALEARLGRRR TVQEARALLRCRRAGISAPV VFFVDYASNCLYMEEIEGSV TVRDYIQSTMETEKTPQGLS NLAKTIGQVLARMHDEDLIH GDLTTSNMLLKPPLEQLNIV LIDFGLSFISALPEDKGVDL YVLEKAFLSTHPNTETVFEA FLKSYSTSSKKARPVLKKL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-253 of human TP53RK (NP_291028.3). |
Additional Info
| Tissue Specificity | Highly expressed in testis. Weakly expressed in heart kidney and spleen. |
| Function | Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP. Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation. |
| Protein Name | Ekc/Keops Complex Subunit Tp53rkAtypical Serine/Threonine Protein Kinase Tp53rkNori-2Tp53-Regulating KinaseP53-Related Protein Kinase |
| Database Links | Reactome: R-HSA-6782315Reactome: R-HSA-6804756 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Ekc/Keops Complex Subunit Tp53rk antibodyAnti-Atypical Serine/Threonine Protein Kinase Tp53rk antibodyAnti-Nori-2 antibodyAnti-Tp53-Regulating Kinase antibodyAnti-P53-Related Protein Kinase antibodyAnti-TP53RK antibodyAnti-C20orf64 antibodyAnti-PRPK antibody |
Information sourced from Uniprot.org