| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Type 2 DNA topoisomerase 6 subunit B-like (93-143 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TOP6BL |
| Gene ID: |
79703 |
| Uniprot ID: |
TO6BL_HUMAN |
| Immunogen Region: |
93-143 aa |
| Specificity: |
This antibody detects endogenous levels of CK080 at Human |
| Immunogen: |
Synthesized peptide derived from the human CK080 at the amino acid range 93-143 |
| Function | Isoform 3: Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. |
| Protein Name | Type 2 Dna Topoisomerase 6 Subunit B-LikeTop6b Like Initiator Of Meiotic Double Strand BreaksType 2 Dna Topoisomerase Vi Subunit B-LikeTopovibl |
| Cellular Localisation | ChromosomeLocalizes To Meiotic Chromosomes |
| Alternative Antibody Names | Anti-Type 2 Dna Topoisomerase 6 Subunit B-Like antibodyAnti-Top6b Like Initiator Of Meiotic Double Strand Breaks antibodyAnti-Type 2 Dna Topoisomerase Vi Subunit B-Like antibodyAnti-Topovibl antibodyAnti-TOP6BL antibodyAnti-C11orf80 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
