| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-DNA topoisomerase 2-beta (1-50 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TOP2B |
| Gene ID: | 7155 |
| Uniprot ID: | TOP2B_HUMAN |
| Immunogen Region: | 1-50 aa |
| Specificity: | Topo II Beta Polyclonal Antibody detects endogenous levels of Topo II Beta protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human TOP2B at the amino acid range 1-50 |
| Post Translational Modifications | (Microbial infection) Deubiquitinated by Epstein-Barr virus BPLF1.leading to stabilized SUMOylated TOP2A trapped in cleavage complexes, which halts the DNA damage response to TOP2A-induced double-strand DNA breaks. SUMOylated. |
| Function | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. |
| Protein Name | Dna Topoisomerase 2-BetaDna Topoisomerase Ii - Beta Isozyme |
| Database Links | Reactome: R-HSA-4615885 |
| Cellular Localisation | NucleusNucleolusNucleoplasm |
| Alternative Antibody Names | Anti-Dna Topoisomerase 2-Beta antibodyAnti-Dna Topoisomerase Ii - Beta Isozyme antibodyAnti-TOP2B antibody |
Information sourced from Uniprot.org
