| Tissue Specificity | Ubiquitous.highest in skeletal muscle, heart, brain and fetal liver. |
| Function | Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. |
| Protein Name | Dna Topoisomerase I - MitochondrialTop1mt |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Dna Topoisomerase I - Mitochondrial antibodyAnti-Top1mt antibodyAnti-TOP1MT antibody |
Information sourced from Uniprot.org
