Anti-TNS4/CTEN antibody (STJA0038078)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human TNS4
General Information
| Short Description | Rabbit monoclonal anti-TNS4/CTEN for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purified |
| Dilution Range | IHC 1:100-1:200 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | TNS4 |
| Gene ID | 84951 |
| Uniprot ID | TENS4_HUMAN |
| Immunogen | A synthesized peptide derived from human TNS4 |
Additional Info
| Tissue Specificity | Expressed at low levels in colon (at protein level). Expressed in prostate and placenta. |
| Post Translational Modifications | Proteolytically cleaved by caspase-3 during apoptosis. |
| Function | Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration. Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF. Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration. |
| Protein Name | Tensin-4C-Terminal Tensin-Like Protein |
| Database Links | Reactome: R-HSA-8875513 |
| Cellular Localisation | Cell JunctionFocal AdhesionCytoplasmCytoskeleton |
| Alternative Antibody Names | Anti-Tensin-4 antibodyAnti-C-Terminal Tensin-Like Protein antibodyAnti-TNS4 antibodyAnti-CTEN antibodyAnti-PP14434 antibody |
Information sourced from Uniprot.org