| Short Description : | Rabbit monoclonal Troponin T (199-298) antibody for use in IHC-P, IF, ICC and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC-P/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S5MR |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | IHC-P:1:50-1:200IF/ICC:1:50-1:200 |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TNNT2 |
| Gene ID: | 7139 |
| Uniprot ID: | TNNT2_HUMAN |
| Immunogen Region: | 199-298 |
| Immunogen Sequence: | QKQAQTERKSGKRQTEREKK KKILAERRKVLAIDHLNEDQ LREKAKELWQSIYNLEAEKF DLQEKFKQQKYEINVLRNRI NDNQKVSKTRGKAKVTGRWK |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 199-298 of human Cardiac troponin T (TNNT2) (P45379). |
| Tissue Specificity | Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. |
| Post Translational Modifications | Phosphorylation at Thr-213 by PRKCA induces significant reduction in myofilament calcium sensitivity and actomyosin ATPase activity. |
| Function | Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| Protein Name | Troponin T - Cardiac MuscleTntcCardiac Muscle Troponin TCtnt |
| Database Links | Reactome: R-HSA-390522 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Troponin T - Cardiac Muscle antibodyAnti-Tntc antibodyAnti-Cardiac Muscle Troponin T antibodyAnti-Ctnt antibodyAnti-TNNT2 antibody |
Information sourced from Uniprot.org
