Host: | Rabbit |
Applications: | WB/IHC/IF |
Reactivity: | Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit monoclonal antibody anti-Troponin T (199-298) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
Clonality: | Monoclonal |
Clone ID: | S5MR |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:2000-1:5000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | TNNT2 |
Gene ID: | 7139 |
Uniprot ID: | TNNT2_HUMAN |
Immunogen Region: | 199-298 |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 199-298 of human Cardiac troponin T (TNNT2) (P45379). |
Immunogen Sequence: | QKQAQTERKSGKRQTEREKK KKILAERRKVLAIDHLNEDQ LREKAKELWQSIYNLEAEKF DLQEKFKQQKYEINVLRNRI NDNQKVSKTRGKAKVTGRWK |
Tissue Specificity | Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. |
Post Translational Modifications | Phosphorylation at Thr-213 by PRKCA induces significant reduction in myofilament calcium sensitivity and actomyosin ATPase activity. |
Function | Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
Protein Name | Troponin T - Cardiac Muscle Tntc Cardiac Muscle Troponin T Ctnt |
Database Links | Reactome: R-HSA-390522 |
Alternative Antibody Names | Anti-Troponin T - Cardiac Muscle antibody Anti-Tntc antibody Anti-Cardiac Muscle Troponin T antibody Anti-Ctnt antibody Anti-TNNT2 antibody |
Information sourced from Uniprot.org