| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TNFRSF21 (371-655) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TNFRSF21 |
| Gene ID: |
27242 |
| Uniprot ID: |
TNR21_HUMAN |
| Immunogen Region: |
371-655 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 371-655 of human TNFRSF21 (NP_055267.1). |
| Immunogen Sequence: |
RKSSRTLKKGPRQDPSAIVE KAGLKKSMTPTQNREKWIYY CNGHGIDILKLVAAQVGSQW KDIYQFLCNASEREVAAFSN GYTADHERAYAALQHWTIRG PEASLAQLISALRQHRRNDV VEKIRGLMEDTTQLETDKLA LPMSPSPLSPSPIPSPNAKL ENSALLTVEPSPQDKNKGFF VDESEPLLRCDSTSSGSSAL SRNGSFITKEKKDTVLRQVR LDPCDLQPIFDDMLHFLNP |
| Tissue Specificity | Detected in fetal spinal cord and in brain neurons, with higher levels in brain from Alzheimer disease patients (at protein level). Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes. |
| Post Translational Modifications | Oxidized in response to reactive oxygen species (ROS), leading to endocytosis. |
| Function | Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21.this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation. Also acts as a regulator of pyroptosis: recruits CASP8 in response to reactive oxygen species (ROS) and subsequent oxidation, leading to activation of GSDMC. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 21Death Receptor 6Cd Antigen Cd358 |
| Database Links | Reactome: R-HSA-1989781 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinEndocytosed Following Oxidation In Response To Reactive Oxygen Species (Ros) |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 21 antibodyAnti-Death Receptor 6 antibodyAnti-Cd Antigen Cd358 antibodyAnti-TNFRSF21 antibodyAnti-DR6 antibodyAnti-UNQ437 antibodyAnti-PRO868 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
