Host: | Rabbit |
Applications: | WB |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-TIM-1/KIM-1/HAVCR (22-237) is suitable for use in Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:2000-1:8000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | Havcr1 |
Gene ID: | 171283 |
Uniprot ID: | HAVR1_MOUSE |
Immunogen Region: | 22-237 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-237 of mouse TIM-1/KIM-1/HAVCR (NP_599009.2). |
Immunogen Sequence: | YVEVKGVVGHPVTLPCTYST YRGITTTCWGRGQCPSSACQ NTLIWTNGHRVTYQKSSRYN LKGHISEGDVSLTIENSVES DSGLYCCRVEIPGWFNDQKV TFSLQVKPEIPTRPPTRPTT TRPTATGRPTTISTRSTHVP TSIRVSTSTPPTSTHTWTHK PEPTTFCPHETTAEVTGIPS HTPTDWNGTVTSSGDTWSNH TEAIPPGKPQKNPTKG |
Tissue Specificity | Expressed by stimulated T-cells. Expressed during primary antigen stimulation. Expressed at higher levels on B rather than T-cells, both constitutively and after activation. |
Function | Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions. As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses. Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease. Regulates also expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10. Acts as regulator of T-cell proliferation. May play a role in kidney injury and repair. |
Protein Name | Hepatitis A Virus Cellular Receptor 1 Homolog Havcr-1 Kidney Injury Molecule 1 Kim-1 T Cell Immunoglobulin And Mucin Domain-Containing Protein 1 Timd-1 T Cell Membrane Protein 1 T-Cell Immunoglobulin Mucin Receptor 1 Tim-1 Cd Antigen Cd365 |
Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
Alternative Antibody Names | Anti-Hepatitis A Virus Cellular Receptor 1 Homolog antibody Anti-Havcr-1 antibody Anti-Kidney Injury Molecule 1 antibody Anti-Kim-1 antibody Anti-T Cell Immunoglobulin And Mucin Domain-Containing Protein 1 antibody Anti-Timd-1 antibody Anti-T Cell Membrane Protein 1 antibody Anti-T-Cell Immunoglobulin Mucin Receptor 1 antibody Anti-Tim-1 antibody Anti-Cd Antigen Cd365 antibody Anti-Havcr1 antibody Anti-Kim1 antibody Anti-Tim1 antibody Anti-Timd1 antibody |
Information sourced from Uniprot.org