Anti-TIM-1/KIM-1/HAVCR antibody (22-237) (STJ11105360)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TIM-1/KIM-1/HAVCR (22-237) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:2000-1:8000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Havcr1 |
| Gene ID | 171283 |
| Uniprot ID | HAVR1_MOUSE |
| Immunogen Region | 22-237 |
| Immunogen Sequence | YVEVKGVVGHPVTLPCTYST YRGITTTCWGRGQCPSSACQ NTLIWTNGHRVTYQKSSRYN LKGHISEGDVSLTIENSVES DSGLYCCRVEIPGWFNDQKV TFSLQVKPEIPTRPPTRPTT TRPTATGRPTTISTRSTHVP TSIRVSTSTPPTSTHTWTHK PEPTTFCPHETTAEVTGIPS HTPTDWNGTVTSSGDTWSNH TEAIPPGKPQKNPTKG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 22-237 of mouse TIM-1/KIM-1/HAVCR (NP_599009.2). |
Additional Info
| Tissue Specificity | Expressed by stimulated T-cells. Expressed during primary antigen stimulation. Expressed at higher levels on B rather than T-cells, both constitutively and after activation. |
| Function | Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions. As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses. Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease. Also regulates expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10. Acts as a regulator of T-cell proliferation. May play a role in kidney injury and repair. |
| Protein Name | Hepatitis A Virus Cellular Receptor 1 HomologHavcr-1Kidney Injury Molecule 1Kim-1T Cell Immunoglobulin And Mucin Domain-Containing Protein 1Timd-1T Cell Membrane Protein 1T-Cell Immunoglobulin Mucin Receptor 1Tim-1Cd Antigen Cd365 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Hepatitis A Virus Cellular Receptor 1 Homolog antibodyAnti-Havcr-1 antibodyAnti-Kidney Injury Molecule 1 antibodyAnti-Kim-1 antibodyAnti-T Cell Immunoglobulin And Mucin Domain-Containing Protein 1 antibodyAnti-Timd-1 antibodyAnti-T Cell Membrane Protein 1 antibodyAnti-T-Cell Immunoglobulin Mucin Receptor 1 antibodyAnti-Tim-1 antibodyAnti-Cd Antigen Cd365 antibodyAnti-Havcr1 antibodyAnti-Kim1 antibodyAnti-Tim1 antibodyAnti-Timd1 antibody |
Information sourced from Uniprot.org