Anti-TIAL1 antibody (STJA0009733)

SKU:
STJA0009733

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Nucleolysin TIAR is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TIAL1
Gene ID: 7073
Uniprot ID: TIAR_HUMAN
Specificity: This antibody detects endogenous levels of TIAR at Human, Mouse
Immunogen: Synthesized peptide derived from human TIAR
Post Translational Modifications Phosphorylated by MAPK14 following DNA damage, releasing TIAR from GADD45A mRNA.
Function RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation. Shows a preference for uridine-rich RNAs. Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA. Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1. Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.
Protein Name Nucleolysin Tiar
Tia-1-Related Protein
Database Links Reactome: R-HSA-6803529
Cellular Localisation Nucleus
Cytoplasm
Cytolytic Granule
Stress Granule
Nuclear Import Seems To Be Coupled To Rna Polymerase Ii Transcription And May Be Dependent On Rna-Binding
Accumulates In Cytoplasmic Stress Granules (Sg) Following Cellular Damage
Alternative Antibody Names Anti-Nucleolysin Tiar antibody
Anti-Tia-1-Related Protein antibody
Anti-TIAL1 antibody

Information sourced from Uniprot.org

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