• Immunohistochemistry analysis of paraffin-embedded mouse kidney using TGF beta Receptor II (TGFBR2) Rabbit monoclonal antibody (STJ11104851) at dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of paraffin-embedded human placenta using TGF beta Receptor II (TGFBR2) Rabbit monoclonal antibody (STJ11104851) at dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.

Anti-TGFBR2 antibody (200-300) [S4851RM] (STJ11104851)

SKU:
STJ11104851

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Host: Rabbit
Applications: IHC
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-Tgf-Beta Receptor Type-2 (200-300) is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: S4851RM
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TGFBR2
Gene ID: 7048
Uniprot ID: TGFR2_HUMAN
Immunogen Region: 200-300
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 200-300 of human TGF beta Receptor II (TGFBR2) (NP_003233.4).
Immunogen Sequence: TWETGKTRKLMEFSEHCAII LEDDRSDISSTCANNINHNT ELLPIELDTLVGKGRFAEVY KAKLKQNTSEQFETVAVKIF PYEEYASWKTEKDIFSDINL K
Post Translational Modifications Phosphorylated on a Ser/Thr residue in the cytoplasmic domain.
Function Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and thus regulates a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. Isoform 1: Has transforming growth factor beta-activated receptor activity. Isoform 2: Has transforming growth factor beta-activated receptor activity. Isoform 3: Binds TGFB1, TGFB2 and TGFB3 in the picomolar affinity range without the participation of additional receptors. Blocks activation of SMAD2 and SMAD3 by TGFB1.
Protein Name Tgf-Beta Receptor Type-2
Tgfr-2
Tgf-Beta Type Ii Receptor
Transforming Growth Factor-Beta Receptor Type Ii
Tgf-Beta Receptor Type Ii
Tbetar-Ii
Database Links Reactome: R-HSA-2173788
Reactome: R-HSA-2173789
Reactome: R-HSA-2173791
Reactome: R-HSA-3304356
Reactome: R-HSA-3642279
Reactome: R-HSA-3645790
Reactome: R-HSA-3656532
Reactome: R-HSA-3656535
Reactome: R-HSA-5689603
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Membrane Raft
Isoform 3: Secreted
Alternative Antibody Names Anti-Tgf-Beta Receptor Type-2 antibody
Anti-Tgfr-2 antibody
Anti-Tgf-Beta Type Ii Receptor antibody
Anti-Transforming Growth Factor-Beta Receptor Type Ii antibody
Anti-Tgf-Beta Receptor Type Ii antibody
Anti-Tbetar-Ii antibody
Anti-TGFBR2 antibody

Information sourced from Uniprot.org

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