Anti-TFB1M antibody (28-346) (STJ117425)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TFB1M (28-346) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TFB1M |
| Gene ID | 51106 |
| Uniprot ID | TFB1M_HUMAN |
| Immunogen Region | 28-346 |
| Immunogen Sequence | QAAKQLSQNFLLDLRLTDKI VRKAGNLTNAYVYEVGPGPG GITRSILNADVAELLVVEKD TRFIPGLQMLSDAAPGKLRI VHGDVLTFKVEKAFSESLKR PWEDDPPNVHIIGNLPFSVS TPLIIKWLENISCRDGPFVY GRTQMTLTFQKEVAERLAAN TGSKQRSRLSVMAQYLCNVR HIFTIPGQAFVPKPEVDVGV VHFTPLIQPKIEQPFKLVEK VVQNVFQFRRKYCHRGLRM |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 28-346 of human TFB1M (NP_057104.2). |
Additional Info
| Tissue Specificity | Ubiquitously expressed. |
| Function | Mitochondrial methyltransferase which uses S-adenosyl methionine to dimethylate two highly conserved adjacent adenosine residues (A1583 and A1584) within the loop of helix 45 at the 3-prime end of 12S rRNA, thereby regulating the assembly or stability of the small subunit of the mitochondrial ribosome. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. |
| Protein Name | Dimethyladenosine Transferase 1 - MitochondrialMitochondrial 12s Rrna Dimethylase 1Mitochondrial Transcription Factor B1H-MttfbH-Mttfb1Htfb1mMttfb1S-Adenosylmethionine-6-N' - N'-Adenosyl(Rrna Dimethyltransferase 1 |
| Database Links | Reactome: R-HSA-2151201Reactome: R-HSA-6793080 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Dimethyladenosine Transferase 1 - Mitochondrial antibodyAnti-Mitochondrial 12s Rrna Dimethylase 1 antibodyAnti-Mitochondrial Transcription Factor B1 antibodyAnti-H-Mttfb antibodyAnti-H-Mttfb1 antibodyAnti-Htfb1m antibodyAnti-Mttfb1 antibodyAnti-S-Adenosylmethionine-6-N' - N'-Adenosyl(Rrna Dimethyltransferase 1 antibodyAnti-TFB1M antibodyAnti-CGI-75 antibody |
Information sourced from Uniprot.org