| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Transcription Factor Ap-2-Alpha (100-200) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TFAP2A |
| Gene ID: |
7020 |
| Uniprot ID: |
AP2A_HUMAN |
| Immunogen Region: |
100-200 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human Activator protein 2 (AP-2/TFAP2A) (NP_003211.1). |
| Immunogen Sequence: |
RQSQESGLLHTHRGLPHQLS GLDPRRDYRRHEDLLHGPHA LSSGLGDLSIHSLPHAIEEV PHVEDPGINIPDQTVIKKGP VSLSKSNSNAVSAIPINKDN L |
| Post Translational Modifications | Sumoylated on Lys-10.which inhibits transcriptional activity. |
| Function | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. |
| Protein Name | Transcription Factor Ap-2-AlphaAp2-AlphaAp-2 Transcription FactorActivating Enhancer-Binding Protein 2-AlphaActivator Protein 2Ap-2 |
| Database Links | Reactome: R-HSA-3232118 P05549-1Reactome: R-HSA-8864260Reactome: R-HSA-8866904Reactome: R-HSA-8866906Reactome: R-HSA-8866907Reactome: R-HSA-8866910Reactome: R-HSA-8866911Reactome: R-HSA-8869496 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Ap-2-Alpha antibodyAnti-Ap2-Alpha antibodyAnti-Ap-2 Transcription Factor antibodyAnti-Activating Enhancer-Binding Protein 2-Alpha antibodyAnti-Activator Protein 2 antibodyAnti-Ap-2 antibodyAnti-TFAP2A antibodyAnti-AP2TF antibodyAnti-TFAP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
