| Post Translational Modifications | Lactylation by AARS1 promotes nuclear localization and stabilization of YAP1, leading to increased Hippo signaling pathway. Delactylated by SIRT1. |
| Function | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. |
| Protein Name | Transcriptional Enhancer Factor Tef-1Ntef-1Protein Gt-IicTea Domain Family Member 1Tead-1Transcription Factor 13Tcf-13 |
| Database Links | Reactome: R-HSA-2032785Reactome: R-HSA-8951671Reactome: R-HSA-9619665 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcriptional Enhancer Factor Tef-1 antibodyAnti-Ntef-1 antibodyAnti-Protein Gt-Iic antibodyAnti-Tea Domain Family Member 1 antibodyAnti-Tead-1 antibodyAnti-Transcription Factor 13 antibodyAnti-Tcf-13 antibodyAnti-TEAD1 antibodyAnti-TCF13 antibodyAnti-TEF1 antibody |
Information sourced from Uniprot.org
