• Immunohistochemical analysis of paraffin-embedded human Small intestinal stromal tumor. 1, Tris-EDTA, pH9.0 was used for antigen retrieval. 2 Antibody was diluted at 1:200 (4°C overnight. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).

Anti-TEAD1 antibody (30-110 aa) (STJ95961)

SKU:
STJ95961

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Transcriptional enhancer factor TEF-1 (30-110 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TEAD1
Gene ID: 7003
Uniprot ID: TEAD1_HUMAN
Immunogen Region: 30-110 aa
Specificity: TEF-1 Polyclonal Antibody detects endogenous levels of TEF-1 protein.
Immunogen: Synthesized peptide derived from TEF-1 at the amino acid range 30-110
Function Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.
Protein Name Transcriptional Enhancer Factor Tef-1
Ntef-1
Protein Gt-Iic
Tea Domain Family Member 1
Tead-1
Transcription Factor 13
Tcf-13
Database Links Reactome: R-HSA-2032785
Reactome: R-HSA-8951671
Reactome: R-HSA-9619665
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Transcriptional Enhancer Factor Tef-1 antibody
Anti-Ntef-1 antibody
Anti-Protein Gt-Iic antibody
Anti-Tea Domain Family Member 1 antibody
Anti-Tead-1 antibody
Anti-Transcription Factor 13 antibody
Anti-Tcf-13 antibody
Anti-TEAD1 antibody
Anti-TCF13 antibody
Anti-TEF1 antibody

Information sourced from Uniprot.org

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