• Immunohistochemistry with Anti-TDRD1 Antibody (STJ503224) at 1:100 dilution in Buffer. DAB (brown) staining and Haematoxylin QS (blue) counterstain. 40X magnification on Leica DM4000B. FFPE section.

Anti-TDRD1 antibody (570-605) (STJ503224)

SKU:
STJ503224-100

£441.50
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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TDRD1 (570-605) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.52-0.53 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
IHC: 1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: TDRD1
Gene ID: 56165
Uniprot ID: TDRD1_HUMAN
Immunogen Region: 570-605
Immunogen: Synthetic peptide taken within amino acid region 570-605 on TDRD1 protein.
Tissue Specificity Testis and ovary specific. Also expressed in several cancers.
Function Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins.
Protein Name Tudor Domain-Containing Protein 1
Cancer/Testis Antigen 41.1
Ct41.1
Database Links Reactome: R-HSA-5601884
Cellular Localisation Cytoplasm
Component Of The Meiotic Nuage
Also Named P Granule
A Germ-Cell-Specific Organelle Required To Repress Transposon Activity During Meiosis
Also Present In Chromatoid Body
Alternative Antibody Names Anti-Tudor Domain-Containing Protein 1 antibody
Anti-Cancer/Testis Antigen 41.1 antibody
Anti-Ct41.1 antibody
Anti-TDRD1 antibody

Information sourced from Uniprot.org

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