| Background | T cell receptor (TCR) is a heterodimer consisting of an Alpha and a Beta chain (TCR Alpha/Beta ) or a Gamma and a Delta chain (TCR Gamma/Delta ). TCR Gamma/Delta belongs to the immunoglobulin superfamily, involved in the recognition of certain bacterial and tumor antigens bound to MHC class I. The TCR Gamma/Delta associates with CD3 and is expressed on a T cell subset found in the thymus, the intestinal epithelium, and the peripheral lymphoid tissues and peritoneum. Most Gamma/Delta T cells are CD4-/CD8-, some are CD8+. T cells expressing the TCR Gamma/Delta have been shown to play a role in oral tolerance, tumor-associated tolerance, and autoimmune disease. It has been reported that Gamma/Delta T cells also play a principal role in antigen presentation. Immobilized UC7-13D5 antibody has been reported to activate TCR-Gamma/Delta-bearing T cells in vitro, and to deplete peripheral TCR-Gamma/Delta-bearing T cells in vivo. |
Information sourced from Uniprot.org
