• Western blot analysis of extracts of various cell lines, using TCF7L1 antibody (STJ11105742) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-TCF7L1 antibody (260-340) (STJ11105742)

SKU:
STJ11105742

£112.50 - £522.50
Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Transcription Factor 7-Like 1 (260-340) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TCF7L1
Gene ID: 83439
Uniprot ID: TF7L1_HUMAN
Immunogen Region: 260-340
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 260-340 of human TCF7L1 (NP_112573.1).
Immunogen Sequence: YSLPPGGFRHPYPALAMNAS MSSLVSSRFSPHMVAPAHPG LPTSGIPHPAIVSPIVKQEP APPSLSPAVSVKSPVTVKKE E
Tissue Specificity Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium.
Function Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. Down-regulates NQO1, leading to increased mitomycin c resistance.
Protein Name Transcription Factor 7-Like 1
Hmg Box Transcription Factor 3
Tcf-3
Database Links Reactome: R-HSA-201722
Reactome: R-HSA-3769402
Reactome: R-HSA-4086398
Reactome: R-HSA-4411364
Reactome: R-HSA-4641265
Reactome: R-HSA-8951430
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Transcription Factor 7-Like 1 antibody
Anti-Hmg Box Transcription Factor 3 antibody
Anti-Tcf-3 antibody
Anti-TCF7L1 antibody
Anti-TCF3 antibody

Information sourced from Uniprot.org

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