• Western blot analysis of lysates from Rat lung, using TCF1/TCF7 Rabbit monoclonal antibody (STJ11104080) at1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
  • Western blot analysis of various lysates using TCF1/TCF7 Rabbit monoclonal antibody (STJ11104080) at1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.

Anti-TCF7 antibody (50-150) [S4080RM] (STJ11104080)

SKU:
STJ11104080

£146.50 - £639.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-Transcription Factor 7 (50-150) is suitable for use in Western Blot research applications.
Clonality: Monoclonal
Clone ID: S4080RM
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TCF7
Gene ID: 6932
Uniprot ID: TCF7_HUMAN
Immunogen Region: 50-150
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human TCF1/TCF7 (NP_003193.2).
Immunogen Sequence: ELKSSLVNESEGAAGGAGIP GVPGAGAGARGEAEALGREH AAQRLFPDKLPEPLEDGLKA PECTSGMYKETVYSAFNLLM HYPPPSGAGQHPQPQPPLHK A
Tissue Specificity Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium.
Function Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages. Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes.
Protein Name Transcription Factor 7
Tcf-7
T-Cell-Specific Transcription Factor 1
T-Cell Factor 1
Tcf-1
Database Links Reactome: R-HSA-201722
Reactome: R-HSA-3769402
Reactome: R-HSA-4086398
Reactome: R-HSA-4411364
Reactome: R-HSA-4641265
Reactome: R-HSA-8951430
Reactome: R-HSA-9754189
Reactome: R-HSA-9796292
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Transcription Factor 7 antibody
Anti-Tcf-7 antibody
Anti-T-Cell-Specific Transcription Factor 1 antibody
Anti-T-Cell Factor 1 antibody
Anti-Tcf-1 antibody
Anti-TCF7 antibody
Anti-TCF1 antibody

Information sourced from Uniprot.org

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