Host: | Rabbit |
Applications: | WB/IF |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-TBL1XR1 (120-170) is suitable for use in Western Blot and Immunofluorescence research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:1000 IF/ICC 1:50-1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | TBL1XR1 |
Gene ID: | 79718 |
Uniprot ID: | TBL1R_HUMAN |
Immunogen Region: | 120-170 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-170 of human TBL1XR1 (NP_078941.2). |
Immunogen Sequence: | QQGSAKNGENTANGEENGAH TIANNHTDMMEVDGDVEIPP NKAVVLRGHES |
Tissue Specificity | Widely expressed including the pituitary, hypothalamus, white and brown adipose tissue, muscle and liver. |
Function | F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. |
Protein Name | F-Box-Like/Wd Repeat-Containing Protein Tbl1xr1 Nuclear Receptor Corepressor/Hdac3 Complex Subunit Tblr1 Tbl1-Related Protein 1 Transducin Beta-Like 1x-Related Protein 1 |
Database Links | Reactome: R-HSA-1368082 Reactome: R-HSA-1368108 Reactome: R-HSA-1989781 Reactome: R-HSA-2122947 Reactome: R-HSA-2151201 Reactome: R-HSA-2426168 Reactome: R-HSA-2644606 Reactome: R-HSA-2894862 Reactome: R-HSA-3214815 Reactome: R-HSA-350054 Reactome: R-HSA-381340 Reactome: R-HSA-400206 Reactome: R-HSA-400253 Reactome: R-HSA-9022537 Reactome: R-HSA-9022692 Reactome: R-HSA-9029569 Reactome: R-HSA-9609690 Reactome: R-HSA-9707564 Reactome: R-HSA-9707616 |
Cellular Localisation | Nucleus |
Alternative Antibody Names | Anti-F-Box-Like/Wd Repeat-Containing Protein Tbl1xr1 antibody Anti-Nuclear Receptor Corepressor/Hdac3 Complex Subunit Tblr1 antibody Anti-Tbl1-Related Protein 1 antibody Anti-Transducin Beta-Like 1x-Related Protein 1 antibody Anti-TBL1XR1 antibody Anti-IRA1 antibody Anti-TBLR1 antibody |
Information sourced from Uniprot.org